Thanks for the explanation. Indeed, checking "Message about different binary files" allows the comparison to complete, even though I cannot display the differences.
I must admit, however, I'm still baffled by why the memory cannot be allocated. Even according to your worst case, 2 files * 70 MB * 6 = 840 MB << 4 GB (physical + swapfile).
I have been monitoring memory usage with both Task Manager and Everest. Everest seems to be reporting that EDP is using 1786 MB! (see Used Virtual Memory) Even so, I don't understand why physical memory is being depleted while plenty of swap space remains available.
Windows memory management has always baffled me.

Does any of this make sense to you?
note, values are before / after running EDP
Physical Memory
---------------
Total 1023 MB / 1023 MB
Used 224 MB / 1014 MB
Free 799 MB / 9 MB
Utilization 22 % / 99 %
Swap Space
----------
Total 3926 MB / 3926 MB
Used 126 MB / 1123 MB
Free 3799 MB / 2803 MB
Utilization 3 % / 29 %
Virtual Memory
--------------
Total 4949 MB / 4949 MB
Used 351 MB / 2137 MB
Free 4598 MB / 2812 MB
Utilization 7 % / 43 %